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Lycibarbarspermidine L from Goji Berry Promotes Intestinal Restoration in an Antibiotic-Induced Rat Model through
Xueni Zhang1, Xiaoyan Wen1, Di Zhou1,2
1School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Abstract:
Oral antibiotics damage gut epithelium while treating infections. Goji berry derives from Lycium barbarum L., which is employed as a dietary and tonic herb with the effect of promoting intestinal health. The spermidine compound lycibarbarspermidine L (LBS L) in it can promote intestinal epithelial growth. The purpose of the research is to examine the reparative effects of LBS L against antibiotic-stimulated gut epithelial damage, as well as the processes associated with T-UCR. Intestinal epithelial cells were stimulated with antibiotics to induce injury. The impact of LBS L and T-UCR-related mechanisms was evaluated through cell assays. Ultimately, a rat model of intestinal injury was developed by administering antibiotics. We found that LBS L reversed the intestinal damage caused by antibiotics through modulating uc.141A/miR195-3p. A reduction in intestinal damage was observed in rat models. In conclusion, LBS L ameliorates antibiotic-induced intestinal epithelial cell damage in rats by modulating uc.141A.
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