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Evaluating green solvents for sustainable PLGA nanoparticle synthesis
Senjuti Karmaker1, Rhea Joshi1, Amartya Viravalli1
1Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA. nboehnke@umn.edu.
Biomaterials Science
|May 13, 2025
Abstract:
We report the synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) using sustainable green solvents as safer alternatives to traditional petroleum-based, hazardous solvents. The resulting NPs are stable and exhibit comparable physicochemical properties and cellular uptake to those synthesized with traditional solvents, highlighting the potential of green solvents for NP synthesis.

