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Solvent control of E/Z selectivity in palladium-catalyzed semi-hydrogenation of alkynes
Yuang Chen1, Tianna Jing1, Zhihua Cai1
1School of Chemistry and Chemical Engineering/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, Shihezi University, Shihezi, Xinjiang 832003, China. bqq880219@163.com.
Abstract:
A solvent-controlled stereoselective semi-reduction of alkynes with excellent stereoselectivity and chemoselectivity was accomplished by palladium catalysis. Various Z-alkenes were achieved with formic acid as the hydrogen source when the reaction was conducted in DMSO, while E-alkenes were obtained in toluene under otherwise identical reaction conditions. Detailed mechanism studies suggested that the alkyne hydrogenation gave Z-alkene intermediates. The E-alkene product was generated by a Z to E alkene isomerization process in toluene, and the Z-alkene was stabilized by employing DMSO as the solvent.
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