Expression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma

Masako Noumi ^1,2, Michiyo Higashi ^1,3, Ikumi Kitazono ¹

⁰Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Histology and Histopathology +

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May 13, 2025

View abstract on PubMed

Summary

Mucin expression, specifically MUC1 and MUC4, can predict outcomes in gallbladder adenocarcinoma (GBAC). High MUC1 indicates a worse prognosis, while MUC4 suggests a better outcome for GBAC patients.

Area Of Science

Oncology
Gastroenterology
Biomarker Research

Background

Gallbladder adenocarcinoma (GBAC) has a poor prognosis due to late detection.
Identifying reliable prognostic factors is essential for effective GBAC patient management.

Purpose Of The Study

To investigate the correlation between mucin expression profiles (MUC1, MUC2, MUC4) and clinicopathological features in resected GBAC.
To determine if mucin expression serves as a prognostic indicator for GBAC survival.

Main Methods

Immunohistochemical analysis of MUC1, MUC2, and MUC4 expression in early-stage GBAC tissues.
Comparison of mucin expression prevalence with clinicopathological characteristics and patient outcomes.

Main Results

MUC1 expression correlated with lymphatic, vascular, and perineural invasion, and recurrence.
High MUC1 expression was linked to worse patient prognosis, while MUC4 expression was associated with better prognosis.
MUC2 expression showed a link to perineural invasion and recurrence, but not directly to prognosis.

Conclusions

MUC1 and MUC4 expression are independent prognostic factors for survival in GBAC.
These mucins can serve as valuable biomarkers for predicting patient outcomes in gallbladder adenocarcinoma.