Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

51.5K
Overview
51.5K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

2.9K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
2.9K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

468
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
468
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

396
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
396
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.1K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.1K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Rapid clinical identification of vulnerable older adults in acute and emergency care: narrative review of short geriatric screening tools.

Frontiers in medicine·2026
Same author

Rapid clinical identification of vulnerable older adults in acute and emergency care: narrative review of short geriatric screening tools.

Frontiers in medicine·2026
Same author

An international, multispecialty consensus document on the optimal management of patients with internal carotid artery occlusion.

Journal of vascular surgery·2026
Same author

Optimal treatment of preclinical cardiovascular disease: A narrative review with a focus on carotid artery stenosis.

Seminars in vascular surgery·2026
Same author

Changes in Systemic Inflammatory Marker Levels Following Percutaneous Revascularisation of Lower Extremity Arteries.

International journal of molecular sciences·2026
Same author

An international, expert-based, multispecialty Delphi consensus document on stroke risk stratification and the optimal management of patients with asymptomatic and symptomatic carotid stenosis.

Journal of vascular surgery·2025

Related Experiment Video

Updated: May 14, 2025

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.9K

Atherosclerotic plaque stabilization and regression.

Pavel Poredoš1,2, Ana Spirkoska Mangaroska1, Peter Poredoš2,3

  • 1Department of Vascular Disease, University Medical Centre Ljubljana, Slovenia.

VASA. Zeitschrift Fur Gefasskrankheiten
|May 13, 2025
PubMed
Summary

Atherosclerotic plaque regression, assessed non-invasively, is achievable with lipid-lowering therapies. However, linking plaque regression to reduced cardiovascular events requires further investigation for personalized patient management.

Keywords:
Atherosclerotic plaquescardiovascular eventslipid-lowering therapyregressionstabilization

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

1.9K

Related Experiment Videos

Last Updated: May 14, 2025

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

9.9K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
13:45

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

1.9K

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Pharmacology

Background:

  • Atherosclerotic plaques are a primary cause of cardiovascular events.
  • Plaque progression and composition significantly increase cardiovascular risk.
  • Non-invasive imaging modalities now allow for detailed assessment of plaque characteristics.

Purpose of the Study:

  • To review the role of plaque assessment in managing cardiovascular risk.
  • To explore the potential of plaque imaging in guiding personalized patient management.
  • To evaluate the association between plaque regression and cardiovascular event reduction.

Main Methods:

  • Literature review of clinical trials and studies on atherosclerotic plaque imaging.
  • Analysis of data from studies using advanced imaging techniques to assess plaque volume and composition.
  • Synthesis of evidence on the impact of lipid-lowering and anti-atherosclerotic therapies on plaque characteristics.

Main Results:

  • Reducing low-density lipoprotein (LDL) cholesterol levels effectively reduces atherosclerotic plaque burden and improves plaque composition.
  • Statin therapy and novel agents like PCSK9 inhibitors demonstrate efficacy in plaque modification.
  • Anti-inflammatory and other anti-atherosclerotic drugs can also significantly reduce plaque burden.

Conclusions:

  • Non-invasive plaque assessment offers promising avenues for monitoring treatment response.
  • Further research is needed to establish a definitive link between plaque regression and reduced cardiovascular events.
  • Plaque assessment may play a future role in personalizing cardiovascular disease management strategies.