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Fertility-sparing treatment for patients with endometrial cancer: a bibliometric analysis from 2000 to 2024

Yue Gao1, Huali Wang1, Meng Jiang1

  • 1Department of Gynecology, Dalian Women and Children's Medical Center (Group), Dalian, Liaoning, China.

Frontiers in Oncology
|May 13, 2025
PubMed
Abstract

Insights

This study analyzed fertility-sparing endometrial cancer (EC) treatments, revealing key research trends and top contributors. Findings highlight hormonal therapies and prognostic factors, guiding future reproductive oncology research.

Area of Science:

  • Reproductive Medicine
  • Gynecological Oncology
  • Bibliometrics

Background:

  • Rising global incidence of endometrial cancer (EC), especially in younger patients.
  • Growing importance of fertility-sparing treatment in gynecological and reproductive medicine.
  • Limited comprehensive bibliometric analyses in this critical field.

Purpose of the Study:

  • To conduct the most extensive bibliometric analysis of fertility-sparing EC treatments to date.
  • To identify leading contributors, research trends, and knowledge networks.
  • To provide actionable insights for future research in reproductive oncology.

Main Methods:

  • Systematic bibliometric analysis of 506 publications (2000-2024).
  • Utilized CiteSpace, JepaC, and VOSviewer for data analysis.
  • Evaluated contributions by region, institution, author, journal, and keywords.

Main Results:

  • China and the US are leading contributors (44.3%).
  • Fudan University and Cha University are most active institutions.
  • Key themes include progestin, reproductive outcomes, age, prognostic factors, and myometrial invasion.

Conclusions:

  • The field emphasizes hormonal therapies and prognostic determinants.
  • Need for standardized treatment protocols and long-term fertility outcome studies.
  • Analysis maps research trajectories to guide future reproductive oncology investigations.
Keywords:
bibliometric analysisendometrial cancerfertility-sparing treatmentmolecular classificationprogestin

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