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Related Experiment Video

Updated: May 14, 2025

Three-Dimensional Printing of a Complex Aortic Anomaly
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Three-Dimensional (3D) Printing for Left Atrial Appendage Occlusion Device Sizing: A Systematic Review and

Jasneel S Kahlam1, Olga V Savinova2, Don D Shamilov3

  • 1Internal Medicine, Stony Brook Southampton, Southampton, USA.

Cureus
|May 13, 2025
PubMed
Summary

Three-dimensional (3D) printing enhances left atrial appendage (LAA) occlusion planning by improving device sizing and implantation accuracy. This technology can reduce device usage, procedure time, and complications like leaks in patients with nonvalvular atrial fibrillation.

Keywords:
3d ct3d printing3d teeadditive manufacturingleft atrial appendage occlusionrapid prototyping

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • The left atrial appendage (LAA) is a primary site for thrombus formation in nonvalvular atrial fibrillation (NVAF), increasing stroke risk.
  • LAA occlusion is an alternative to anticoagulation for NVAF patients with contraindications.
  • Accurate device sizing is crucial for successful LAA occlusion.

Purpose of the Study:

  • To systematically review the use of 3D printing in planning left atrial appendage occlusion procedures.
  • To evaluate the impact of 3D printing on device sizing accuracy and procedural outcomes.

Main Methods:

  • A literature search was conducted using keywords related to LAA, 3D printing, and occlusion.
  • 16 studies employing 3D printing for LAA device sizing and/or deployment were included.
  • Data on anatomical measurements, device sizing, implantation, and procedural outcomes were extracted.

Main Results:

  • 3D-printed models improved anatomical measurements, device sizing, and implantation compared to standard methods.
  • Studies reported reduced device usage per procedure (e.g., 1.7 to 1.1) and shorter procedure times.
  • 3D printing was associated with fewer perivascular leaks and residual shunts.

Conclusions:

  • 3D printing shows significant potential for improving procedural planning and outcomes in LAA occlusion.
  • Larger, multicenter studies are needed to further validate the clinical benefits of 3D printing in this application.
  • Future research should explore personalized 3D-printed occlusion devices for LAA thrombosis treatment.