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Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
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Left Atrial Reverse Remodeling in Patients Supported With Durable Left Ventricular Assist Devices and Clinical
Christos P Kyriakopoulos1,2, Konstantinos Sideris1, Iosif Taleb1,3
1Division of Cardiovascular Medicine, Department of Internal Medicine (C.P.K., K.S., I.T., E. Tseliou, J.A., A.S.B., M.J.B., M.N., E.D., T.C.H., S.C., J.S., O.W.-P., S.R., E. Tumarkin, S.G.D.), University of Utah Health and School of Medicine, Salt Lake City.
Circulation. Heart Failure
|May 13, 2025
Summary
Left atrial reverse remodeling improves with LVAD support and is linked to better survival. This finding may guide advanced heart failure therapy and atrial fibrillation management.
Area of Science:
- Cardiology
- Cardiac Surgery
- Biomedical Engineering
Background:
- The left atrium (LA) and left ventricle (LV) have a dynamic relationship.
- LA remodeling impacts prognosis in chronic heart failure patients.
- Investigating LA reverse remodeling in LVAD patients is crucial.
Purpose of the Study:
- To examine LA reverse remodeling in patients supported by LV assist devices (LVADs).
- To determine the impact of LA reverse remodeling on clinical outcomes.
- To explore the association between LA and LV structural/functional changes.
Main Methods:
- Prospective evaluation of 241 advanced heart failure patients receiving continuous-flow LVADs.
- Serial echocardiographic assessments pre- and post-LVAD implantation.
- Analysis of LA/LV structure, function, and association with mortality, adverse events, and atrial fibrillation (AF).
Main Results:
- LA structure and function significantly improved by 1 month and remained stable at 12 months post-LVAD.
- LA reverse remodeling magnitude correlated with all-cause mortality.
- 61% of patients with pre-LVAD AF converted to sinus rhythm.
Conclusions:
- LVAD support promotes early and sustained LA reverse remodeling, associated with LV changes.
- LA reverse remodeling impacts all-cause mortality and AF conversion.
- Findings may inform advanced heart failure therapy and management of patients with AF.
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