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Updated: Aug 1, 2026

One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013
Precisely Tailored Annulated Porphyrin with Intense NIR Absorption for Highly Efficient Photothermal Therapy and
Chulin Qu1, Chengyan Zhao1, Yingzhe Hu2
1State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China.
Abstract:
Constructing near-infrared (NIR) phototherapy agents with good biosafety is highly desirable for cancer therapy. Herein, the combined "β-meso-core" engineering of porphyrin produces excellent photothermal/photoacoustic agents that exhibit locally excited NIR bands with high molar extinction coefficients reaching 105 scale. The β-anthracene fusion of porphyrins via retro-Diels-Alder reactions extends the π-systems, generating red-shifted and intensified Q bands with narrow half-widths. The change of meso-substituents leads to distorted, non-aggregated molecules with improved solubility and fine-tunes the photophysical characteristics. The core coordination of copper ions promotes non-radioactive decay in the energy-releasing process and enhances photobleaching resistance. The biocompatible nanoparticles encapsulating the designed porphyrin exhibit a high photothermal conversion efficiency of 68% and promising photoacoustic responses, enabling effective photoacoustic imaging-guided photothermal therapy in vivo at a safe laser intensity (808 nm, 0.3 W cm- 2). This study provides a novel strategy in the molecular engineering of porphyrin for designing highly efficient photothermal agents.
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