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Updated: May 14, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Psychological Distress, Post-Traumatic Stress and Emotional Suppression in a Pregnancy After a Perinatal Death: A
Joanna Beaumont1, Debbie Smith2, Emilie Bailey3
1Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, UK.
Objective:
To evaluate parents' psychological distress and emotional suppression in the antenatal and postnatal periods of a pregnancy following a perinatal death.
Design:
Questionnaire.
Setting:
Tertiary Maternity Unit in the UK.
Sample:
Parents who were pregnant and attending a specialist antenatal clinic for pregnancy after loss.
Methods:
Partners and mothers completed questionnaire measures which evaluated their levels of depression, anxiety, post-traumatic stress (PTS) and emotional suppression at 23 and 32 weeks' gestation, and 6 weeks postnatally. Repeated measures ANOVA or Friedman tests were used to identify significant changes in scores. Independent samples t-tests or Mann-Whitney U tests were used to determine significant differences in partners' and mothers' group scores. The proportion of partners and mothers scoring above threshold for each measure was identified, and a one-sample t-test examined partners' and mothers' within-couple scores.
Main Outcome Measures:
Psychological distress and emotional suppression.
Results:
Fifty-one partners and 54 mothers completed the questionnaire. Partners', but not mothers', depression symptoms significantly decreased (p = 0.004; 95% CI 0.6-2.7) from 23 weeks' gestation (M = 11.32, SD = 5.35) to 32 weeks' gestation (M = 9.68, SD = 4.68). Mothers' depression symptoms significantly decreased (z = -3.91, p < 0.001) from 32 weeks gestation (median value of 13; IQR 8-17) to 6 weeks postnatal (median value of 10; IQR 5-13). Parents' anxiety levels did not change across the course of pregnancy. Mothers', but not partners', anxiety symptoms significantly decreased (z = -2.49, p = 0.013) from 32 weeks' gestation (median value of 7.5; IQR 4-14) to 6 weeks postnatal (median value of 6; IQR 2-13). PTS did not change across the course of a pregnancy, and mothers' symptoms continued into the postnatal period. Partners are more likely to hide their emotions during pregnancy than mothers (z = 3.35, p < 0.001).
Conclusion:
Parents who have experienced a prior perinatal death are likely to experience symptoms of anxiety, depression and PTS in a subsequent pregnancy. Anxiety in partners and PTS in mothers may continue into the postnatal period. Specialist mental health support (e.g., counselling) offered within a dedicated pregnancy after loss service is one way to support parents. Further research is needed to determine whether psychological distress impacts negatively on parent-child bonding.
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