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Updated: May 14, 2025

Operation of the Collaborative Composite Manufacturing CCM System
Published on: October 1, 2019
Cs2CO3-N,N-Dimethylacetamide-Promoted Esterification of Arylformic Acids with a-Bromo Esters via Nucleophilic
Xinyan Song1, Mingxin Li1, Haihong Bao1
1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Abstract:
Herein, a nucleophilic substitution reaction between arylformic acids and α-bromo esters, facilitated by a Cs2CO3-DMA system, is reported. This reaction occurs under mild conditions, yielding a diverse range of valuable lactic acid derivatives (34 examples) with good to excellent yields (up to 97%). Subtle factors, such as the ion-dipole interactions between Cs2CO3, the substrates, and the solvent, may significantly influence the dynamics of the SN2 reaction.
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