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Updated: May 1, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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An Environmentally Responsive Molecular Engineering Framework for Subcellular Drug Translocalization

Guiqian Fang1, Daili Liu1, Qingjie Bai1

  • 1State Key Laboratory of Advanced Drug Delivery and Release Systems, School of Pharmaceutical Sciences, School of Life Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|May 13, 2025
PubMed
Summary

This study introduces an engineered organelle visualization drug-delivery system (OVDS) to overcome cancer drug resistance. The OVDS facilitates drug movement from lysosomes to mitochondria, enhancing cancer cell treatment.

Keywords:
drug resistancelysosomesmitochondriasubcellularsuper‐resolution imaging

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