Related Experiment Video
Updated: May 14, 2025

Rigid Embedding of Fixed and Stained, Whole, Millimeter-Scale Specimens for Section-free 3D Histology by Micro-Computed Tomography
Published on: October 17, 2018
Diagnosing the first patient: Integrating histopathology into an undergraduate gross anatomy course
Kyle A Robertson1, Megan Kruskie2, Jessica N Byram2
1Department of Anatomy, Cell Biology, & Physiology, Indiana University School of Medicine, West Lafayette, Indiana, USA.
Abstract:
The incorporation of humanism through exploration of pathology in gross anatomy allows students to develop a deeper appreciation of the pathological basis of disease and to explore the impacts of pathology on donors' lives through clinicopathologic correlation of their findings. The purpose of this short communication was to describe and evaluate a pilot intervention that integrated histopathology into an existing humanism thread, First Patient Project (FPP), in an undergraduate, dissection-based gross anatomy course. Five reflections were collected from each student (n = 18 students, 90 reflections) and a post-course questionnaire collected data on student perceptions of the FPP and integrations of histopathology. Content analysis was used to analyze reflection and survey free response data, and descriptive statistics were performed on Likert-style items using Excel. The questionnaire was completed by six students (33%) and five themes comprise the perceived impacts of the integration of histopathology into the FPP: pathology deepens anatomy knowledge, promotes career exploration, novice medical professionals, reflections of donor pathology and lifestyle, and general feedback on histopathology integration. Student reflections demonstrated that the histopathology component of the FPP improved clinical understanding of pathology, helped facilitate feelings of belonging in the medical profession, and allowed them to reflect on their own humanity as well as that of the donors. This ultimately demonstrated that histology and particular histopathology from anatomic donors were feasible and provided an avenue for curricular integration and adding another layer of appreciation of the donors' clinical history.
More Related Videos
Related Concept Videos
Histology of the Gastrointestinal (GI) Tract
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...
Histology of the Large Intestine
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
Fixation and Sectioning
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...

