[Changes in the phospholipid composition of rat liver chromatin during treatment with hydrocortisone]

When isolating protein components of chromatin from the rat liver phospholipids are found in the fraction of nonhistone proteins but not in that of histone. Administration of hydrocortisone to animals evokes a reliable increase of the phospholipids of hydrocortisone to animals evokes a reliable increase of the phospholipids amount in the preparations of chromatin and labile-bound nonhistone proteins. In this case the fraction of phosphatidylcholine lowers considerably with a simultaneous increase of sphingomyelin and phosphatidylethanolamine. It is supposed that phospholipid metabolism in chromatin is controlled by hormones, which may be significant for mechanisms of the genetic apparatus activation by steroid hormones.