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Functionalized Interventional System for in Situ Hematologic Cell Capture.

Ying Yu1, Yuan Cheng2, Shiwei Xu1

  • 1College of Engineering and Applied Sciences, MOE Key Laboratory of High-Performance Polymer Materials and Technology, Nanjing University, Nanjing 210023, China.

ACS Applied Materials & Interfaces
|May 13, 2025
PubMed
Summary
This summary is machine-generated.

A novel in situ hematologic cell capture (FISHC) system uses a functionalized wire to directly isolate fetal nucleated red blood cells (FNRBCs) from maternal blood. This minimally invasive technology advances noninvasive prenatal diagnosis (NIPD) and liquid biopsy applications.

Keywords:
Antibody conjugationFetal nucleated red blood cellsNoninvasive prenatal diagnosisPeripheral bloodSurface-modified guidewire

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Area of Science:

  • Biomedical Engineering
  • Genetics
  • Obstetrics

Background:

  • Noninvasive prenatal diagnosis (NIPD) using fetal cells is safer than invasive methods but hindered by low fetal nucleated red blood cell (FNRBC) counts and inefficient isolation.
  • Current techniques require blood withdrawal and ex vivo processing, limiting practical application.

Purpose of the Study:

  • To develop and validate a functionalized interventional system for in situ hematologic cell capture (FISHC) directly from peripheral blood.
  • To enable efficient and minimally invasive retrieval of fetal cells for NIPD.

Main Methods:

  • A carboxybetaine methacrylate (CBMA)-functionalized medical wire was developed with immobilized FNRBC-specific antibodies.
  • The FISHC system was designed for in situ cell capture directly from peripheral blood under physiological conditions.
  • In vivo validation was performed in a pregnant monkey model.

Main Results:

  • The FISHC system demonstrated high-specificity capture of FNRBCs.
  • Feasibility of efficient and minimally invasive fetal cell retrieval was confirmed in a pregnant monkey model.
  • The system eliminates the need for blood withdrawal and ex vivo processing.

Conclusions:

  • FISHC offers a paradigm shift in cell-based NIPD by enabling direct, in situ fetal cell capture.
  • This technology holds significant promise for improving NIPD and expanding to other applications like circulating tumor cell detection and real-time liquid biopsy.