Treatment Strategies and Effectiveness in Lymphatic Malformations: A 10-Year Retrospective Study
- M Shiraishi 1,2, M Narushima 1, C H Banda 1,3, Y Moriwaki 2, K Kojima 1, K Yamagata 1, C Kondo 1, K Mitsui 1, K Hashimoto 1, K Danno 1, K Hosomi 1, R Ishiura 1,4, M Kurita 2,5, I Koshima 6,7
- M Shiraishi 1,2, M Narushima 1, C H Banda 1,3
- 1Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
- 2Department of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, Japan.
- 3Plastic and Reconstructive Surgery Unit, Department of Surgery, The University Teaching Hospital, Lusaka, Zambia.
- 4Department of Plastic Surgery and Reconstructive Surgery, St Vincent's Private Hospital, East Melbourne, Australia.
- 5Altos Labs, Inc. 5510 Morehouse Drive, Suite 300, San Diego, CA, USA.
- 6International Center for Lymphedema, Hiroshima University Hospital, Hiroshima, Japan.
- 7Department of Plastic and Reconstructive Surgery, Hiroshima University Hospital, Hiroshima, Japan.
- 0Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
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View abstract on PubMed
Summary
This summary is machine-generated.Recurrence of lymphatic malformations (LMs) is common. Lymphaticovenular anastomosis (LVA) shows promise for LM treatment, while microcystic LMs are a risk factor for recurrence.
Area Of Science
- Vascular Surgery
- Pediatric Surgery
- Medical Research
Background
- Lymphatic malformations (LMs) present a significant global challenge due to high recurrence rates post-treatment.
- Identifying factors influencing LM recurrence and comparing treatment efficacy are crucial for improving patient outcomes.
Purpose Of The Study
- To investigate risk factors associated with lymphatic malformation recurrence.
- To compare the effectiveness of surgical versus endovascular treatments for LMs.
Main Methods
- A 10-year retrospective multi-center chart review (2009-2019) of patients treated for LMs.
- Data analysis included post-treatment size, symptoms, recurrence, and comparison of treatment modalities using stepwise multiple regression.
Main Results
- Resection demonstrated the highest recurrence rate (36.4%, p=0.04).
- Lymphaticovenular anastomosis (LVA) showed excellent results in size reduction, symptom alleviation, and recurrence, though not statistically significant.
- Microcystic LM type was identified as an independent risk factor for recurrence.
Conclusions
- Both surgical and endovascular approaches effectively improve LM size and symptoms.
- LVA appears to offer superior outcomes regarding recurrence compared to resection.
- Understanding risk factors like microcystic LM type can aid in treatment selection and progression prediction.
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