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Updated: May 23, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
Cdk activation by phosphorylation: linking growth signals to cell cycle control
Heidi M Blank1, Eun-Gyu No1, Michael Polymenis1
1Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd., College Station, Texas 77843, U.S.A.
Abstract:
Cells adjust their proliferation in response to extrinsic factors and nutrients. Such inputs must reach the cell cycle machinery to ensure proper cell proliferation. This minireview focuses on evidence suggesting that phosphorylating the T-loop domain of cyclin-dependent kinases may be a critical and conserved conduit for these external signals. Understanding this regulatory mechanism could provide crucial insights into how all eukaryotic cells integrate external information to decide whether or not to divide.
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