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Updated: Jun 13, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering

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Screening for Syphilis Infection During Pregnancy: US Preventive Services Task Force Reaffirmation Recommendation

, Michael Silverstein¹, John B Wong²

¹Brown University, Providence, Rhode Island.

|May 13, 2025

Summary

This summary is machine-generated.

Universal syphilis screening during pregnancy is recommended by the US Preventive Services Task Force (USPSTF). Early screening offers substantial benefits, preventing congenital syphilis and its severe infant complications.

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Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

Area of Science:

Obstetrics and Gynecology
Infectious Diseases
Public Health

Background:

Untreated syphilis in pregnant individuals can lead to congenital syphilis.
Congenital syphilis causes severe infant health problems, including stillbirth, neonatal death, and developmental abnormalities.
US congenital syphilis cases are at a 30-year high, with 3882 cases reported in 2023.

Purpose of the Study:

To update evidence on the benefits and harms of screening for syphilis infection in pregnant individuals.
To inform recommendations for syphilis screening in pregnancy.

Main Methods:

Evidence-based review commissioned by the US Preventive Services Task Force (USPSTF).
Focused on benefits and harms of syphilis screening in pregnant populations.

Main Results:

Screening for syphilis infection in pregnancy demonstrates a substantial net benefit.
High certainty supports the conclusion that screening is beneficial.

Conclusions:

The USPSTF recommends universal, early screening for syphilis in pregnant individuals.
Screening should occur at the first opportunity if not done early in pregnancy.