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Area of Science:

  • Environmental Health
  • Gerontology
  • Epidemiology

Background:

  • High-altitude exposure triggers adaptive responses with potential health consequences.
  • The specific impact of high altitudes on accelerated aging and related changes remains unclear.

Purpose of the Study:

  • To investigate the association between high-altitude exposure and biological aging.
  • To explore the relationship between high-altitude living and aging-related metrics.
  • To inform prevention and treatment strategies for aging deficits in high-altitude communities.

Main Methods:

  • A population-based, cross-sectional study utilizing data from two cohorts in Western China (WCNPCS and WCHAT).
  • High-altitude exposure was defined as residing at altitudes >= 1500m.
  • Biological aging and aging acceleration were assessed using Klemera-Doubal Biological Age (KDM-BA) and PhenoAge methods.

Main Results:

  • High-altitude residents exhibited accelerated biological aging (KDM-BA: 0.71-0.85 years; PhenoAge: 2.08-2.23 years).
  • Accelerated aging was more pronounced in smokers residing at high altitudes.
  • Significant associations were found between high-altitude exposure and various aging-related metrics.

Conclusions:

  • Extended high-altitude exposure may accelerate biological aging and increase the risk of aging-related diseases.
  • Public health interventions are recommended for high-altitude populations to reduce the burden of aging-associated illnesses.