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T- and B-cell lymphomas in 2 captive green tree pythons.

Sara Pagliarani1, Luke Haydock1, Leonardo Susta1

  • 1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|May 13, 2025
PubMed
Summary

Two green tree pythons were diagnosed with distinct lymphomas. One python had a T-cell lymphoma, while the other presented with a novel B-cell lymphoma in snakes.

Keywords:
B-cell lymphomaCD3Morelia viridisPAX5T-cell lymphomagreen tree pythonsimmunohistochemistryneoplasmsnakes

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Area of Science:

  • Herpetology
  • Veterinary Pathology
  • Oncology

Background:

  • Lymphoma is a significant neoplastic disease in reptiles.
  • Understanding lymphoma subtypes and diagnostic markers is crucial for reptile care.

Purpose of the Study:

  • To describe two distinct lymphoma cases in green tree pythons (Morelia viridis).
  • To identify the immunophenotypes of these lymphomas using immunohistochemical markers.
  • To report a novel B-cell lymphoma in snakes.

Main Methods:

  • Post-mortem examination of two captive green tree pythons.
  • Histopathological analysis of tissue masses and organs.
  • Immunohistochemical staining for CD3 (T-cell marker) and PAX5 (B-cell marker).

Main Results:

  • The female python had a disseminated leukemic T-cell lymphoma (CD3+).
  • The male python had a B-cell lymphoma (PAX5+), a type not previously reported in snakes.
  • The study highlights the utility of CD3 and PAX5 markers in diagnosing ophidian lymphomas.

Conclusions:

  • Two distinct lymphoma immunophenotypes were identified in green tree pythons.
  • The findings expand the known spectrum of neoplastic diseases in reptiles.
  • Accurate diagnosis and understanding of lymphoma in snakes are vital for improving captive reptile care and management.