Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hand hygiene01:23

Hand hygiene

3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
3.1K
Skin Cancer01:30

Skin Cancer

3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

55
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
55
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

173
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
173

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adult linear IgA bullous dermatosis presenting with a "string of pearls" pattern.

Medicina clinica·2026
Same author

Segmental PASI Evaluation Reveals Reduced PUVA Responsiveness of Lower-Limb Psoriasis in Patients with Internal Organ Malignancy.

Journal of clinical medicine·2026
Same authorSame journal

Cutaneous Polyarteritis Nodosa as the Inaugural Manifestation of Hairy Cell Leukemia.

Acta medica portuguesa·2026
Same author

A multidisciplinary algorithmic approach to psoriasis with cardiovascular comorbidities: integrating dermatology, internal medicine, cardiology and primary care.

Internal medicine journal·2026
Same author

Psoriasis in Obese Patients: Pathophysiological Interactions, Clinical Consequences, and Therapeutic Implications.

Journal of clinical medicine·2026
Same author

Childhood granulomatous periorificial dermatitis: Ivermectin as a novel therapeutic approach.

Dermatology online journal·2026
Same journal

[Sexual Health in Oncology Patients and Cancer Survivors: A Structured Protocol to Address an Unmet Clinical Need at IPO-Porto].

Acta medica portuguesa·2026
Same journal

Hyperthermia in a Teenager: Is it Just a Heat Stroke?

Acta medica portuguesa·2026
Same journal

Alopecia Neoplastica from Breast Carcinoma: When Hair Loss Hides Something Else.

Acta medica portuguesa·2026
Same journal

[Burnout Among Residents: A Current Perspective].

Acta medica portuguesa·2026
Same journal

Ultrasound Characterization of 'To-and-Fro' Waves with Point-of-Care Ultrasound (POCUS) in the Emergency Department Setting.

Acta medica portuguesa·2026
See all related articles

Related Experiment Video

Updated: May 17, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.7K

Update on Generalized Pustular Psoriasis.

Tiago Torres1, Joana Antunes2, Rui Tavares Bello3

  • 1Department of Dermatology. Unidade Local de Saúde de Santo António. Porto. Portugal; Instituto de Ciências Biomédicas Abel Salazar. Universidade do Porto. Porto. Portugal.

Acta Medica Portuguesa
|May 13, 2025
PubMed
Summary
This summary is machine-generated.

Generalized pustular psoriasis (GPP) is a severe skin condition with unique features. Targeted therapies, like spesolimab, are emerging for GPP flares due to understanding the IL-36 pathway.

Keywords:
AntibodiesHumanized/therapeutic useInterleukin /therapeutic useMonoclonalPsoriasis/drug therapy

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

316
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

800

Related Experiment Videos

Last Updated: May 17, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.7K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

316
Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
05:26

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

800

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Generalized pustular psoriasis (GPP) is a severe, rare inflammatory skin disease.
  • GPP is distinct from plaque psoriasis, with unique clinicopathological, immunologic, and genetic profiles.
  • The IL-36 pathway and IL36RN gene mutations are key to GPP pathogenesis.

Purpose of the Study:

  • To provide a comprehensive overview of GPP.
  • To discuss epidemiology, pathophysiology, clinical features, comorbidities, and treatment strategies.
  • To highlight recent advances in targeted GPP therapies.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of GPP pathogenesis, focusing on the IL-36 pathway.
  • Evaluation of diagnostic criteria and disease severity assessment.

Main Results:

  • GPP diagnosis requires integrated clinical, histopathologic, and laboratory data.
  • GPP flares can cause severe systemic complications, including sepsis and multi-organ failure.
  • Spesolimab is the first targeted therapy approved for GPP flares in Europe and the USA.

Conclusions:

  • GPP management is complex, necessitating a thorough understanding of its distinct features.
  • Targeted therapies based on IL-36 pathway dysregulation represent a significant advancement.
  • Continued research is crucial for optimizing GPP treatment strategies.