Related Experiment Video
Updated: May 15, 2025

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
Published on: March 8, 2017
Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction
Ellen K Potoczky1, Alpha S Yap1
1Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072 Australia.
Abstract:
In this issue of Science Signaling, Houtekamer et al. report a mechanism by which adherens junctions enable epithelia to respond to mechanical stress. They demonstrate that E-cadherin-containing adhesions stimulate ERK signaling in response to tissue tension through a metalloproteinase pathway that releases EGF receptor ligands.
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