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Bilateral Idiopathic Multifocal Pigment Epithelial Detachments: A Case Series and Review of Literature

Samer Khateb1, Sean Ghiam2, Jordan Safran2

  • 1Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

Retina (Philadelphia, Pa.)
|May 13, 2025
PubMed

Insights

Idiopathic Multifocal Pigment Epithelial Detachments (IMPED) patients show stable vision long-term, but require monitoring for rare complications like atrophy or choroidal neovascularization (CNV). This rare condition is a diagnosis of exclusion.

Area of Science:

  • Ophthalmology
  • Retinal Diseases

Background:

  • Idiopathic Multifocal Pigment Epithelial Detachments (IMPED) is a rare condition.
  • Gass et al. first described IMPED in 2005.

Purpose of the Study:

  • To describe the longitudinal follow-up of 13 patients diagnosed with IMPED.
  • To assess the long-term prognosis and potential complications of IMPED.

Main Methods:

  • Retrospective case series of 13 patients with bilateral PEDs confirmed by OCT.
  • Ancillary imaging (fundus autofluorescence, angiography) excluded other diagnoses.
  • Electrophysiology (FFERG, EOG) and visual acuity (VA) were monitored over a mean of 6.5 years.

Main Results:

  • All patients maintained stable VA throughout follow-up.
  • Electrophysiology testing was largely normal.
  • Two patients developed outer retinal atrophy; one developed CNV that resolved with treatment.

Conclusions:

  • IMPED is a diagnosis of exclusion, requiring follow-up to confirm no progression.
  • The condition generally has a favorable prognosis but necessitates ongoing monitoring.
  • Long-term risks include atrophy and choroidal neovascularization (CNV).
Abstract

Keywords:
Age-Related Macular DegenerationCase SeriesDrusenIdiopathic Multifocal Pigment Epithelial DetachmentsImaging

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