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Polymer-Based Raman/PET Dual-Modal Probe for Preoperative Tumor Diagnosis and Intraoperative Image-Guided Surgery and

Yuanyuan Qiu1, Qi Zhu2, Kai Cui1

  • 1Department of Pharmacology and Chemical Biology, Institute of Molecular Medicine, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

ACS Applied Materials & Interfaces
|May 13, 2025
PubMed
Summary

A novel substrate-free Raman/PET dual-modal probe, [18F]-AS-DPPT-TT NPs, offers enhanced cancer diagnosis and therapy. This probe enables precise tumor imaging and guided surgery, significantly reducing recurrence rates.

Keywords:
PET imagingin vivo Raman imagingnanomedicinephotothermal therapysurgical navigation

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Cancer Research

Background:

  • Raman imaging and positron emission tomography (PET) offer complementary data for cancer diagnosis and therapy.
  • Existing Raman/PET probes often use surface-enhanced Raman scattering, raising biosafety concerns.
  • A substrate-free approach is needed for safer clinical translation.

Purpose of the Study:

  • To develop a novel, substrate-free Raman/PET dual-modal probe for enhanced cancer management.
  • To integrate strong Raman signals, photothermal effects, PET imaging, and tumor-targeting capabilities.
  • To evaluate the probe's efficacy in preoperative diagnosis, intraoperative guidance, and therapy.

Main Methods:

  • Development of [18F]-AS-DPPT-TT NPs using a biocompatible polymer (DPPT-TT) with strong Raman and photothermal properties.
  • Radiolabeling with fluorine-18 (18F) and functionalization with AS1411 aptamer for tumor targeting.
  • In vivo evaluation in orthotopic colon cancer mouse models for PET and Raman imaging, and photothermal therapy.

Main Results:

  • The [18F]-AS-DPPT-TT NPs demonstrated ultrasensitive resonance Raman signals and significant photothermal effects.
  • Preoperative PET imaging allowed high-contrast whole-body tumor localization.
  • Intraoperative Raman imaging accurately delineated tumor boundaries and detected micrometastases (down to 0.58 mm x 0.32 mm).
  • Raman imaging-guided surgery combined with photothermal therapy led to complete tumor elimination and reduced recurrence.

Conclusions:

  • The developed [18F]-AS-DPPT-TT NPs provide a robust platform for comprehensive tumor management.
  • This substrate-free Raman/PET probe effectively integrates diagnostic and therapeutic capabilities.
  • The probe shows significant potential for improving cancer diagnosis, surgical precision, and therapeutic outcomes.