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Optical Coherence Tomography Biomarkers in Epiretinal Membrane.

Sonya Besagar, Shravika Chennupati, Xiangyu Ji

Ophthalmic Surgery, Lasers & Imaging Retina

|May 13, 2025

Summary

Preoperative optical coherence tomography (OCT) can identify key indicators for idiopathic epiretinal membrane (ERM) surgery. Ellipsoid zone disruption and retinal nerve fiber layer schisis predict better visual outcomes after surgery.

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Area of Science:

Ophthalmology
Retinal Imaging
Surgical Outcomes

Background:

Idiopathic epiretinal membrane (ERM) affects visual acuity.
Predicting visual recovery after ERM surgery is crucial for patient management.

Purpose of the Study:

To identify preoperative optical coherence tomography (OCT) biomarkers.
To predict improved postoperative best-corrected visual acuity (BCVA) in idiopathic ERM patients.

Main Methods:

Retrospective, multicenter imaging analysis of 80 eyes.
Analysis of preoperative OCT, demographic, and surgical factors.
Pars plana vitrectomy, membrane peel, and internal limiting membrane peel (PPV/MP/ILMP) performed.

Main Results:

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Ellipsoid zone (EZ) disruption on OCT predicted improved BCVA.

Focal retinal nerve fiber layer (RNFL) schisis on OCT predicted improved BCVA.

ERM stage, foveal layers, herniation, thickness, cysts, holes, and SUKIMA gap did not predict outcomes.

Conclusions:

Preoperative OCT findings of EZ disruption and RNFL schisis can identify patients likely to experience significant visual improvement after ERM surgery.
These biomarkers aid in surgical decision-making and patient counseling.