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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...

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Published on: September 12, 2014

Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair.

Xiaohui Ju¹, Eliška Javorková^2,3, Jan Michalička⁴

¹Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno 61200, Czech Republic.

|May 13, 2025

Summary

New nanorobots enhance mesenchymal stem cell survival for corneal repair. Cerium oxide with gold single-atom nanorobots (CeSAN-bots) improve cell delivery and promote healing in damaged corneas.

Keywords:

cerium oxide cornea glucose mesenchymal stem cells nanorobot single-atom

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Published on: April 7, 2016

Area of Science:

Biomaterials Science
Regenerative Medicine
Nanotechnology

Background:

Mesenchymal stem cell therapy shows promise for corneal repair but faces challenges with long-term cell survival.
Effective delivery and retention of stem cells are critical for successful corneal regeneration.

Purpose of the Study:

To develop glucose-driven cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for enhanced mesenchymal stem cell delivery and corneal repair.
To investigate the synergistic effects of CeSAN-bots and stem cells in a mouse corneal alkali burn model.

Main Methods:

Design and synthesis of cerium oxide with gold single-atom-based nanorobots (CeSAN-bots).
Evaluation of glucose-powered active motion and cellular uptake efficiency of CeSAN-bots into mesenchymal stem cells.
Assessment of CeSAN-bots' antioxidant and immunomodulatory properties.
In vivo testing in a mouse corneal alkali burn model using stem cells combined with CeSAN-bots.

Main Results:

CeSAN-bots demonstrated enhanced diffusion and active motion powered by glucose via a cascade reaction.
A two-fold increase in cellular uptake efficiency of CeSAN-bots into mesenchymal stem cells was observed compared to passive uptake.
CeSAN-bots exhibited intrinsic antioxidant and immunomodulatory properties beneficial for corneal regeneration.
Combined therapy with stem cells and CeSAN-bots improved corneal clarity restoration in a mouse model.

Conclusions:

CeSAN-bots represent a novel strategy for enzyme-free, glucose-driven nanorobots for targeted intracellular delivery.
The synergistic combination of CeSAN-bots and mesenchymal stem cells shows significant potential for improving corneal regeneration and repair.
This approach offers a promising platform for diverse biological applications requiring enhanced cellular delivery.