Assessment of parameters associated with ovarian function recovery in premenopausal women with early breast cancer and chemotherapy-induced amenorrhea in real-world clinical practice
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View abstract on PubMed
Summary
This summary is machine-generated.Young women undergoing breast cancer chemotherapy can experience menstrual recovery influenced by age and gonadotropin-releasing hormone (GnRH) analog use. Early hormonal profiles can predict ovarian function recovery, aiding patient counseling.
Area Of Science
- Oncology
- Reproductive Endocrinology
- Clinical Research
Background
- Chemotherapy can cause amenorrhea and premature ovarian failure in young breast cancer patients.
- Predictive factors for ovarian function recovery remain poorly understood.
- There is a need for validated markers of ovarian function recovery in clinical practice.
Purpose Of The Study
- To assess factors impacting menses recovery in premenopausal women with early breast cancer.
- To identify predictors of ovarian function recovery post-chemotherapy.
- To evaluate the impact of menses recovery on disease-free survival.
Main Methods
- Retrospective analysis of 308 premenopausal early breast cancer patients treated with chemotherapy.
- Evaluation of factors including age, hormonal treatments, HER2 status, GnRH analog use, anthracycline use, and baseline hormonal profiles (FSH, LH, E2).
- Assessment of menses recovery as the primary endpoint and its association with disease-free survival.
Main Results
- Age and prophylactic use of GnRH analogs significantly impacted menses recovery (p < 0.0001).
- Adjuvant hormonal treatment prolonged time to menses recovery (p < 0.0001), especially in younger patients.
- Baseline FSH, LH, and estradiol levels were significant predictors of menstrual recovery.
Conclusions
- Identified key parameters for predicting ovarian function recovery in premenopausal breast cancer survivors.
- Findings can guide clinical counseling regarding fertility and ovarian function post-chemotherapy.
- Absence of menses recovery showed a trend towards improved disease-free survival.
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