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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Cyclodextrin-based rotaxanes as a versatile platform for biological and medicinal applications
Sapir Paryente1, Hajar Aledwan1, Abed Saady2
1Department of Chemistry, Bar-Ilan University, Ramat Gan, Israel.
Abstract:
Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes attract significant interest due to their unique structures and dynamic properties. Cyclodextrin-based rotaxanes (CD-rotaxanes) have emerged as promising supramolecular systems for biological and medicinal applications. Their host-guest interactions and mechanical bonds provide enhanced stability, stimuli-responsiveness, and tunable functionality. This review highlights their roles in targeted therapy, controlling drug release, theranostic agents, enzyme inhibitor, gene transport and bioimaging. Challenges and future perspectives in translating CD-rotaxanes to biomedical applications are discussed, emphasizing their potential as a next-generation therapeutic platform.
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