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Periungual pigmented Bowen's disease infected with human papillomavirus 73 and healed with secondary intention
Guangdong Wen1, Xiaojie Wang1, Yuxin Wang1
1Department of Dermatology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Abstract:
Periungual pigmented Bowen's disease is uncommon and often overlooked in daily practice. This retrospective observational case series included periungual Bowen's disease diagnosed as by histopathology between January, 2023, and September, 2024, at Peking University People's Hospital. Clinical characteristics, HPV expression and treatment options were evaluated. Four patients (3 males and 1 female) aged 24 to 62 years old were included in the study. All lesions were pigmented and located on the right hand, with the right 3rd finger involved in 3 cases. Two patients reported trauma before the emergence of the lesion and 1 patient had acute myelocytic leukemia. HPV 73 was detected in all patients and 1 patient also carried HPV 52. One patient was treated with imiquimod. Three patients healed well after excision and secondary intention healing. This study highlights the importance of HPV 73 in periungual pigmented Bowen's disease and secondary intention healing in the periungual area.
Insights
Periungual pigmented Bowen's disease, though rare, is linked to HPV 73. This study found surgical excision and secondary intention healing effective for these nail-adjacent skin cancers.
Area of Science:
- Dermatology
- Oncology
- Virology
Background:
- Periungual pigmented Bowen's disease is a rare skin cancer variant.
- Often overlooked, it requires specific diagnostic and treatment considerations.
Purpose of the Study:
- To evaluate clinical characteristics, human papillomavirus (HPV) types, and treatment outcomes for periungual pigmented Bowen's disease.
- To highlight the role of HPV 73 in this specific condition.
Main Methods:
- Retrospective observational case series.
- Histopathological diagnosis of periungual Bowen's disease.
- Analysis of clinical data, HPV detection, and treatment responses.
Main Results:
- Four patients (3 male, 1 female; age 24-62) with pigmented periungual lesions were identified.
- HPV 73 was detected in all cases; HPV 52 was also present in one.
- Three patients achieved successful healing after surgical excision and secondary intention healing.
Conclusions:
- HPV 73 is significantly associated with periungual pigmented Bowen's disease.
- Secondary intention healing is a viable and effective treatment option for periungual lesions.
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