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Laparoscopic Repair of Para-Esophageal Hernia Using Absorbable Biosynthetic Mesh
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Risk factors associated with hiatal hernia: a retrospective study and two-sample Mendelian randomization
Hongyi Dong1, Xing Du1, Jin Zhao2
1Department of General Surgery, Xuanwu Hospital Affiliated to Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.
Surgical Endoscopy
|May 13, 2025
Summary
Male gender, older age, heavy physical labor, and GERD are key risk factors for hiatal hernia. Abdominal obesity and smoking show potential genetic links, while BMI was not significant.
Area of Science:
- Gastroenterology
- Medical Genetics
- Epidemiology
Background:
- Hiatal hernia risk is influenced by factors like gender, BMI, and age.
- Understanding these associations is crucial for risk assessment and management.
Purpose of the Study:
- To investigate the association between gender, BMI, age, and hiatal hernia.
- To utilize retrospective analysis and Mendelian randomization (MR) for comprehensive risk factor evaluation.
Main Methods:
- Retrospective analysis of 685 patients undergoing esophagogastroduodenoscopy (EGD).
- Logistic regression to identify potential risk factors.
- Two-sample MR analysis to validate findings.
Main Results:
- Male sex, older age, heavy physical labor, and GERD were independent risk factors for hiatal hernia.
- MR analysis indicated associations between hiatal hernia and increased waist-hip ratio, trunk fat, smoking initiation, and alcohol intake frequency.
- No statistically significant association was found for increased BMI, general smoking, alcohol consumption, or parity in multivariate analysis.
Conclusions:
- Male gender, advanced age, heavy physical labor, and GERD are confirmed independent risk factors for hiatal hernia.
- Abdominal obesity and smoking may have a genetic predisposition to hiatal hernia.
- Increased BMI did not show a statistically significant association with hiatal hernia in this study.
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