Predictive role of cystatin C and increased proteinuria in early assessment of acute renal toxicity in patient poisoned by nephrotoxic drugs and poisons
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View abstract on PubMed
Summary
This summary is machine-generated.Proteinuria and serum cystatin C effectively predict early kidney damage in acutely poisoned patients. These biomarkers offer a more sensitive approach than traditional methods for detecting drug-induced nephrotoxicity.
Area Of Science
- Nephrology
- Clinical Toxicology
- Biomarker Research
Background
- Acute kidney injury (AKI) is a common complication in critical care, frequently caused by nephrotoxic medications.
- Existing biomarkers like serum creatinine have limitations in the early detection of drug-induced kidney damage.
Purpose Of The Study
- To evaluate the efficacy of proteinuria and serum cystatin C as early indicators of nephrotoxicity in patients with acute poisoning.
- To compare the predictive value of these biomarkers against traditional markers.
Main Methods
- A prospective study of 100 acutely poisoned patients at Sohag University Hospitals.
- Inclusion of patients with symptomatic nephrotoxic effects, requiring at least four blood/urine samples.
- Classification of AKI using Acute Kidney Injury Network (AKIN) criteria and measurement of serum creatinine, proteinuria (ACR), and serum cystatin C.
Main Results
- Serum creatinine levels increased significantly from day 1 to day 2 post-ingestion.
- Serum creatinine, proteinuria ACR, and serum cystatin C were significant predictors of acute renal toxicity.
- Serum cystatin C demonstrated the highest predictive value (AUC = 0.993), followed by day 2 serum creatinine (AUC = 0.873) and proteinuria ACR (AUC = 0.805).
Conclusions
- Proteinuria and serum cystatin C are reliable early predictors of nephrotoxicity in acutely poisoned individuals.
- These biomarkers aid in the early identification and severity assessment of drug-induced kidney injury.
- The findings support the use of cystatin C and proteinuria measurements for enhanced monitoring of kidney function in poisoned patients.
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