Neurological Outcome of Spinal Hemangioblastomas: An International Observational Multicenter Study About 35 Surgical
Motaz Alsereihi1,2, Donato Creatura1,3, Ginevra F D'Onofrio4
1Department of Spine and Spinal Cord Surgery, Hôpital Pierre Wertheimer, GHE, Hospices Civils de Lyon, Claude Bernard University of Lyon 1, 59 Boulevard Pinel, 69677 Lyon, France.
Introduction:
Hemangioblastomas (HBs) are benign, highly vascular tumors that can be found intracranially or in the spinal region, representing around 2-15% of primary intramedullary tumors. They can occur sporadically or in association with Von Hipple-Lindau (VHL) disease. Despite recent of advancement of nonsurgical treatments, complete surgical resection remains the gold standard of care for the spinal HBs.
Materials And Methods:
We conducted an international multicenter retrospective analysis of adult patients surgically treated for spinal HBs in four European referral centers between January 2000 and September 2024, with a minimum post-operative follow-up duration of 6 months. Patients' sex and age at surgical intervention, clinical presentation, and duration symptoms prior to clinical diagnosis were identified. The pre- and post-operative neurological status at 1 and 6 months and at the last visit was assessed using the modified McCormick score (MCS). The extent of surgical resection was divided into gross total resection (GTR) and subtotal resection (STR). Finally, post-operative complications were inspected as well, namely cerebrospinal fluid leaks, infections, hemorrhages and post-operative spinal stability.
Results:
A total of 35 patients were included in the cohort, with an age median of 52 years (34.5-60) and a slight male predominance (21/35, i.e., 60%). The median follow-up period was 37.5 months (12-75). More than half were located in the cervical region, making it the most common (54.3%). Syrinxes were observed in 23 cases (72%), and HBs were more commonly intramedullary (80%). GTR was achievable in around 88% of cases. Post-operative complications were observed in nine patients (25.7%). Nearly half of patients were discharged into rehabilitations centers (48.5%). Tumor recurrence was seen in 10.3% only. At the last follow-up, an excellent overall post-operative neurological status (positive ∆ McCormick) was observed in most of patients (88%) and was found to be associated with a relatively younger age group. Tumor location and presence of syrinxes did not show any statistical significance regarding clinical outcome. In patients having benefited from intra-operative monitoring, only D-wave changes showed statistical significance regarding post-operative outcome (p < 0.05).
Conclusions:
A large majority of patients operated for a spinal HB demonstrated favorable outcome after surgery, with unchanged or improved neurological status. Advanced age could have an impact on the post-operative neurological outcome. Other factors such as tumor size, location, and the presence of syrinx did not seem to significantly impact the neurological outcome. Finally, the surgery of these vascular lesions with no possibility of debulking or piece-meal removal and requiring "en bloc" resection is technically demanding and should be performed by experienced teams in spine and spinal cord surgery only.
