Related Experiment Video
Updated: May 17, 2025
10:26
In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
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A Room for Long-Lived Plasma Cell Contribution in Immune Cytopenias?
Tricia Don1, Manisha Gadgeel2,3, Süreyya Savaşan2,3,4,5,6
1Pediatric Residency, Children's Hospital of Michigan, Detroit, MI 48201, USA.
Cancers
|May 14, 2025
Summary
Long-lived plasma cells (LLPCs) may drive autoimmune cytopenias by persistently producing autoantibodies. Targeting these cells offers potential therapeutic strategies for refractory cases.
Area of Science:
- Immunology
- Hematology
- Autoimmunity
Background:
- Immune cytopenias involve autoantibodies destroying blood cells.
- Current treatments targeting B cells are not always effective.
- Some refractory cases respond to plasma cell-targeted therapies.
Purpose of the Study:
- To review the biology of long-lived plasma cells (LLPCs).
- To summarize evidence implicating LLPCs in immune cytopenias.
- To discuss future therapeutic implications.
Main Methods:
- Literature review of LLPC biology and function.
- Analysis of studies on LLPCs in autoimmune diseases.
- Exploration of genetic and epigenetic factors.
Main Results:
- LLPCs are long-lived, bone marrow-resident antibody producers.
- LLPCs can evade conventional therapies.
- Sustained autoantibody production by LLPCs contributes to immune cytopenias.
Conclusions:
- LLPCs play a significant role in autoimmune cytopenias.
- Targeting LLPCs presents a promising therapeutic avenue.
- Further research into LLPC generation and maintenance is warranted.
Keywords:
B cell developmentEvans syndromeautoantibodiesautoimmune diseasecancerepigeneticsimmune cytopenialong-lived plasma cellsMore Related Videos
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