Could Mesquite (Prosopis juliflora) Help Control Gastrointestinal Parasites in Horses?

Exploring new natural-origin antiparasitic alternatives is essential in addressing the resistance issues that have emerged due to the widespread use of chemical or synthetic antiparasitic compounds. This area remains relatively underexplored despite the increasing recognition of plants like Prosopis juliflora (mesquite) for their antiparasitic properties and nutritional value as a high-protein animal feed. This review aims to investigate the antiparasitic potential of P. juliflora against gastrointestinal parasites in horses. The review incorporates sources from 2005 to 2024. It was found that various phytochemical compounds from P. juliflora, particularly alkaloids, have demonstrated significant antiparasitic activity. Alkaloids are the most studied group due to their antibacterial, antiparasitic, and cytotoxic properties. According to the literature, the phytochemicals produced by P. juliflora hold promise as a potential solution for combating gastrointestinal parasites in horses. However, while preliminary findings suggest promising results, in vivo studies are necessary to evaluate the precise antiparasitic efficacy of these compounds and to determine the appropriate IC50 doses of P. juliflora alkaloids in horses, as well as to assess potential toxicity and side effects associated with their use.