Related Experiment Videos
[Clinical and functional studies of diabetic cardiopathy]
Insights
Diabetics with microangiopathy exhibit impaired cardiac regulation, showing abnormal systolic time intervals and contractility indices even at rest. These cardiac function deficits become more pronounced under orthostatic stress, indicating reduced cardiovascular adaptability.
Area of Science:
- Cardiology
- Diabetology
- Physiology
Context:
- Assessing cardiovascular function in diabetic patients with microangiopathy.
- Evaluating cardiac response to orthostatic stress in healthy individuals and diabetics.
- Investigating the impact of microangiopathy on cardiac performance.
Purpose:
- To determine systolic time intervals and carotid pulse curve contractility indices in diabetics with microangiopathy compared to healthy controls.
- To analyze cardiac responses under resting, passive orthostasis, and active orthostasis conditions.
- To identify specific cardiac regulation abnormalities in diabetics with microangiopathy.
Summary:
- Diabetic patients with microangiopathy demonstrated a tendency towards pathological systolic time intervals and contractility indices at rest.
- Orthostatic stress, particularly using a tilting table, revealed unequivocal deviations in cardiac function in diabetics compared to controls.
- Restricted cardiac regulation breadth in diabetics was evident through reduced reaction of the pre-ejection period (PEP) and left ventricular ejection time (LVET) under orthostasis.
Impact:
- Highlights the subclinical cardiac dysfunction in diabetics with microangiopathy.
- Underscores the importance of assessing cardiovascular autonomic function in diabetic patients.
- Suggests potential for early detection of cardiac complications in diabetes through non-invasive methods.
Abstract:
In 30 diabetics and 30 patients with healthy metabolism who anamnestically, clinically and electrocardiographically did not show any references to a coronary heart disease the systolic time intervals and contractility indices of the carotid pulse curve were determined in lying position as well as under passive and active orthostasis load. Diabetics with a microangiopathy already under conditions of rest showed a tendency to pathological values. Unequivocal deviations were to be registered under conditions of the tilting table, particularly when the values obtained under orthostasis are related to the measuring data in rest. The restricted cardiac regulation breadth of diabetics with microangiopathy is particularly expressed in a compared with the control groups clearly reduced reaction of the presphygmic phase, the time of pressure increase as well as the quotients PEP/LVET, LVET/ICT and PEPstanding/PEPlying.