Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

2.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strength in Numbers: Leveraging Mentorship Teams to Support Medical Student Research in Turbulent Research Environments.

Medical science educator·2026
Same author

Residual microglia following short-term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy.

Aging cell·2024
Same author

Correction to: Early Exposure of Medical Students to a Formal Research Program Promotes Successful Scholarship in a Multi-Campus Medical School.

Medical science educator·2024
Same author

Early Exposure of Medical Students to a Formal Research Program Promotes Successful Scholarship in a Multi-Campus Medical School.

Medical science educator·2024
Same author

Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy.

bioRxiv : the preprint server for biology·2024
Same author

Extracellular Vesicles Derived From Neural Stem Cells, Astrocytes, and Microglia as Therapeutics for Easing TBI-Induced Brain Dysfunction.

Stem cells translational medicine·2023

Related Experiment Video

Updated: May 17, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.3K

Advancing Ischemic Stroke Prognosis: Key Role of MiR-155 Non-Coding RNA.

Catherine Hering1, Gloria M Conover1

  • 1Department of Medical Education, College of Medicine, Texas A&M University, Bryan, TX 77807, USA.

International Journal of Molecular Sciences
|May 14, 2025
PubMed
Summary

MicroRNA-155 (miR-155) is a key regulator in ischemic stroke (IS) pathogenesis. This review explores miR-155

Keywords:
SIRT1apoptosisischemic strokemiR-155microRNAsmicroglia polarizationneuroinflammationneuroprotectionnon-coding RNAsoxidative stressstroke therapeutics

More Related Videos

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.7K
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

570

Related Experiment Videos

Last Updated: May 17, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.3K
A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice
06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

2.7K
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

570

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Ischemic stroke (IS) is a major cause of death and disability globally.
  • Current treatments for IS are limited, offering only supportive care without functional recovery.
  • Understanding IS molecular mechanisms, including oxidative stress, apoptosis, and neuroinflammation, is vital for new therapies.

Purpose of the Study:

  • To review the biological mechanisms of microRNA-155 (miR-155) in ischemic stroke.
  • To evaluate the potential of miR-155 as a biomarker for IS.
  • To explore the therapeutic applications of targeting miR-155 in IS.

Main Methods:

  • Literature review of studies on miR-155 and ischemic stroke.
  • Analysis of molecular pathways involving miR-155 in IS pathogenesis.
  • Examination of data supporting miR-155's role in oxidative homeostasis, apoptosis, and neuroinflammation.

Main Results:

  • MiR-155 is a pro-inflammatory microRNA that is upregulated in ischemic stroke.
  • Dysregulation of miR-155 impacts oxidative homeostasis, apoptosis, and neuroinflammation in IS.
  • Evidence suggests miR-155's involvement in IS progression and severity.

Conclusions:

  • MiR-155 plays a significant role in the molecular pathogenesis of ischemic stroke.
  • MiR-155 holds promise as a diagnostic biomarker for IS.
  • Targeting miR-155 may offer a novel therapeutic strategy for treating IS.