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[How does ketoconazole affect testosterone metabolism?].

W Krause, I Effendy

    Zeitschrift Fur Hautkrankheiten
    |July 15, 1985
    PubMed
    Summary
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    Ketoconazole did not immediately affect testosterone levels in men. However, it delayed the testosterone response to hCG and inhibited testosterone binding to antibodies and SHBG.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Context:

    • Ketoconazole is an antifungal medication.
    • Its potential impact on endocrine function, specifically testosterone synthesis, requires investigation.

    Purpose:

    • To investigate the effects of ketoconazole on testosterone synthesis and binding in healthy young men.

    Summary:

    • Healthy men received ketoconazole (200 mg daily for 7 days).
    • No immediate changes in total or free plasma testosterone were observed.
    • A diminished testosterone response to hCG was noted 24 hours post-treatment.
    • Ketoconazole inhibited testosterone binding to antibodies (RIA) and sex hormone-binding globulin (SHBG).

    Impact:

    • Ketoconazole exhibits a delayed inhibitory effect on testosterone synthesis.

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  • The drug's mechanism involves binding to enzymatic proteins, potentially affecting androgen-binding proteins.
  • Findings suggest ketoconazole can interfere with testosterone's biological interactions.