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Related Concept Videos

Hearing01:31

Hearing

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When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Identification of Risk Loci for Radiotherapy-Induced Tinnitus and Hearing Loss Through Integrated Genomic Analysis.

Fan Ding1, Zehao Pang1, Xiujia Ji1

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|May 14, 2025
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This study identifies genetic variants linked to radiotherapy-induced tinnitus and hearing loss, revealing distinct molecular pathways. Unexpected links to metabolic phenotypes like BMI suggest potential interactions affecting hearing complications.

Keywords:
PheWASgenetic variantshearing lossradiotherapytinnitus

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Area of Science:

  • Genetics
  • Oncology
  • Audiology

Background:

  • Radiotherapy can cause hearing impairment, impacting patient quality of life.
  • The genetic factors contributing to this hearing loss are not well understood.

Purpose of the Study:

  • Identify genetic variants associated with radiotherapy-induced tinnitus and hearing loss.
  • Explore the functional implications and biological pathways involved.
  • Investigate potential links with other health phenotypes.

Main Methods:

  • Genome-wide association study (GWAS) to find single-nucleotide polymorphisms (SNPs).
  • Protein-protein interaction networks and functional enrichment analyses.
  • Phenome-wide association study (PheWAS) across multiple databases.

Main Results:

  • Identified 97 SNPs for tinnitus and 76 SNPs for hearing loss.
  • Tinnitus SNPs linked to Wnt signaling and telomerase RNA pathways.
  • Hearing loss SNPs associated with calcium signaling and neurotransmitter regulation.
  • Significant associations found between hearing-related SNPs and metabolic phenotypes (e.g., BMI).

Conclusions:

  • Distinct genetic architectures underlie radiotherapy-induced tinnitus and hearing loss.
  • Metabolic status may influence susceptibility to radiotherapy-induced hearing damage.
  • Findings support developing genetic screening and targeted interventions for hearing protection.