Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

363
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
363
Disorders of Hemostasis01:24

Disorders of Hemostasis

666
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
666
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

492
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
492
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

10.5K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.5K
Analgesia and Pain Management01:25

Analgesia and Pain Management

403
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
403
Nociception01:44

Nociception

27.6K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic Insights into Piperine-Driven Oxidative Stress, Autophagy Activation and Anti-Migration Effects in Caco-2 Cells.

Molecules (Basel, Switzerland)·2026
Same author

Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas.

Pflugers Archiv : European journal of physiology·2026
Same author

Gastrointestinal Conditions Affect Chronic Pain and Quality of Life in Women.

International journal of environmental research and public health·2024
Same author

Anti-Inflammatory and Antinociceptive Properties of the Quercetin-3-Oleate AV2, a Novel FFAR1 Partial Agonist.

International journal of molecular sciences·2024
Same author

Potential Human Health Benefits of <i>Phaseolus vulgaris</i> L. var Venanzio: Effects on Cancer Cell Growth and Inflammation.

Nutrients·2024
Same author

A Personalized Mediterranean Diet Improves Pain and Quality of Life in Patients with Fibromyalgia.

Pain and therapy·2024

Related Experiment Video

Updated: May 17, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.1K

Fibromyalgia: Chronic Pain Due to a Blood Dysfunction?

Anna Maria Aloisi1, Ilenia Casini1

  • 1Stress and Pain Neurophysiology Laboratory, Department of Medicine, Surgery and Neuroscience University of Siena, 53100 Siena, Italy.

International Journal of Molecular Sciences
|May 14, 2025
PubMed
Summary

Fibromyalgia (FM) symptoms may stem from blood and cardiovascular factors affecting tissue oxygenation. This review highlights blood-related causes and potential interventions for chronic pain in FM patients.

Keywords:
5-HTANSbloodchronic paingonadal hormoneshypoxiavessels

More Related Videos

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.6K
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

4.3K

Related Experiment Videos

Last Updated: May 17, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
08:33

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research

Published on: January 5, 2024

1.1K
Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
06:44

Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain

Published on: June 23, 2009

19.6K
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

4.3K

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Pain Medicine

Background:

  • Fibromyalgia (FM) is a widespread chronic pain disorder affecting all ages, predominantly women.
  • The etiology of FM is unclear, but cardiovascular and blood-related factors are implicated.
  • Abnormalities in blood counts and vascular function can impair tissue oxygenation, potentially contributing to FM symptoms.

Purpose of the Study:

  • To review factors affecting oxygen delivery to tissues in fibromyalgia patients.
  • To explore the role of blood elements and cardiovascular aspects in the pathophysiology of fibromyalgia.
  • To identify potential blood-related interventions for managing chronic pain in FM.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of studies examining hemograms, blood indexes, and vascular function in FM.
  • Synthesis of evidence linking blood parameters and oxygenation to FM symptoms.

Main Results:

  • Blood test results in FM patients often show values at or near normal limits, or outside normal ranges.
  • Vascular regulation of blood flow can be compromised, impacting tissue oxygenation.
  • Hypoxia and blood-related factors are strongly suggested as underlying causes for many FM symptoms.

Conclusions:

  • The physio-pathological basis of most fibromyalgia symptoms appears to be related to blood and cardiovascular function.
  • Blood-related interventions show promise for managing fibromyalgia.
  • Further research into the cardiovascular and hematological aspects of FM is warranted.