Electrochemically Reduced Graphene Oxide Covalently Bound Sensor for Paracetamol Voltammetric Determination

Area of Science:

• Electrochemistry
• Materials Science
• Analytical Chemistry

Background:

• Developing sensitive electrochemical sensors for drug analysis is crucial but challenging.
• Functionalized electrodes are key for enhancing detection capabilities.

Purpose of the Study:

• To develop a highly sensitive and efficient electrochemical sensor for paracetamol (PAR) detection.
• To utilize a modified glassy carbon electrode (GCE) with phenyl diazonium salts (ph) and electrochemically reduced graphene oxide (ERGO).

Main Methods:

• Fabrication of the GCE/ph/ERGO sensor.
• Characterization using SEM, EIS, and CV.
• Detection of paracetamol using square wave voltammetry (SWV).

Main Results:

• The GCE/ph/ERGO sensor showed significantly enhanced conductivity and a higher anodic current peak for PAR compared to bare GCE.
• Achieved a low detection limit of 18.2 nM and a quantification limit of 60.6 nM.
• Demonstrated excellent selectivity, accuracy, and stability, comparable to HPLC.

Conclusions:

• The developed GCE/ph/ERGO sensor is reliable, stable, and robust for routine paracetamol analysis in pharmaceutical samples.
• This sensor offers a promising alternative for precise drug quantification.