Related Experiment Video
Updated: May 17, 2025
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Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers Diethylaminoethyl-cellulose Columns
Published on: April 6, 2019
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Extracellular Vesicles Derived from Trypanosomatids: The Key to Decoding Host-Parasite Communication.
Armanda Rodrigues1, Juliana Inês Weber1, João Durães-Oliveira1
1Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, 1349-008 Lisboa, Portugal.
International Journal of Molecular Sciences
|May 14, 2025
Summary
Trypanosomatid parasites cause neglected zoonotic diseases (NZDs). This review explores how their extracellular vesicles (EVs) mediate host-parasite communication and their potential for controlling these global health threats.
Area of Science:
- Parasitology
- Cell Biology
- Immunology
Background:
- Trypanosomatids are protozoan parasites causing neglected zoonotic diseases (NZDs) with global health implications.
- Extracellular vesicles (EVs) are key mediators of cell-to-cell communication, carrying diverse biomolecules.
- EVs are implicated in both physiological processes and pathological conditions, including immune regulation.
Purpose of the Study:
- To review the role of trypanosomatid-derived EVs in host-parasite interactions.
- To highlight the biological functions of these EVs in leishmaniases and trypanosomiasis.
- To explore the therapeutic potential of EVs in controlling NZDs.
Main Methods:
- Literature review focusing on trypanosomatid-derived EVs.
- Analysis of studies on EV cargo and function.
- Synthesis of current knowledge on EV-mediated host-parasite communication.
Main Results:
- Trypanosomatid EVs modulate host immune responses.
- EVs play a crucial role in the pathogenesis of leishmaniases and trypanosomiasis.
- EVs are involved in intercellular communication between the parasite and the host.
Conclusions:
- Trypanosomatid-derived EVs are significant factors in disease development.
- Understanding EV biology offers novel strategies for controlling trypanosomatid infections.
- EVs represent a promising avenue for developing diagnostics and therapeutics for NZDs.
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