Related Experiment Video

Updated: May 17, 2025

RhoC GTPase Activation Assay
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RhoC GTPase Activation Assay

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Pan-Cancer Analysis Identifies a Ras-Related GTPase as a Potential Modulator of Cancer

Hsiang-Yin Hsueh1,2,3, Kristyn Gumpper-Fedus1,2, Jelmer W Poelstra4

  • 1Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

International Journal of Molecular Sciences
|May 14, 2025
PubMed

Insights

Dexamethasone-induced Ras-related protein 1 (RASD1) is downregulated in many cancers, suggesting a tumor suppressor role. High RASD1 expression correlates with better prognosis and increased immune cell infiltration, indicating its potential in cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Ras signaling is crucial in cancer, but roles of less-studied Ras-related genes are unclear.
  • Dexamethasone-induced Ras-related protein 1 (RASD1) exhibits tumor-suppressive functions (inhibits growth, induces apoptosis).

Purpose of the Study:

  • To investigate RASD1 expression patterns across various human tissues and cancers.
  • To explore the correlation between RASD1 expression, cancer prognosis, and immune cell infiltration.

Main Methods:

  • Analysis of RASD1 mRNA expression using The Cancer Genome Atlas (TCGA), Human Protein Atlas, and Genotype-Tissue Expression (GTEx) databases.
  • Correlation analysis with promoter methylation, patient prognosis, and immune cell infiltration.
  • Exploration of co-expressed genes to infer functional pathways.

Main Results:

  • RASD1 mRNA expression is significantly downregulated in multiple cancer types compared to normal tissues.
  • Downregulation correlates with low promoter methylation; high RASD1 expression is linked to favorable prognosis.
  • Elevated RASD1 expression is associated with increased infiltration of CD4+ T cells and myeloid-derived dendritic cells.

Conclusions:

  • RASD1 functions as a potential tumor suppressor gene with downregulated expression in various cancers.
  • RASD1 expression may serve as a prognostic biomarker and influence anti-tumor immunity.
  • RASD1 potentially modulates immune signaling, interleukin-4-mediated apoptosis, and PTEN gene transcription.
Keywords:
RASD1TCGAcancer prognosisimmune infiltration

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