Early Detection of Alzheimer's Disease via Machine Learning-Based Microwave Sensing: An Experimental Validation

The early diagnosis of Alzheimer's disease remains an unmet medical need due to the cost and invasiveness of current methods. Early detection would ensure a higher quality of life for patients, enabling timely and suitable treatment. We investigate microwave sensing for low-cost, non-intrusive early detection and assessment of Alzheimer's disease. This study is based on the emerging evidence that the electromagnetic properties of cerebrospinal fluid are affected by abnormal concentrations of proteins recognized as early-stage biomarkers. We design a conformal six-element antenna array placed on the upper portion of the head, operating in the 500 MHz to 6.5 GHz band. It measures scattering response due to changes in the dielectric properties of intracranial cerebrospinal fluid. A multi-layer perceptron network extracts the diagnostic information. Data classification consists of two steps: binary classification to identify the disease presence and multi-class classification to evaluate its stage. The algorithm is trained and validated through controlled experiments mimicking various pathological severities with an anthropomorphic multi-tissue head phantom. Results support the feasibility of the proposed method using only amplitude data and lay the foundation for more extensive studies on microwave sensing for early Alzheimer's detection.