Stochastic analysis of 133xe clearance for determining regional cerebral blood flow in a primate model

A technique for stochastic analysis of 133Xe washout using a computer-assisted Anger camera is described. The technique produces functional maps of both regional cerebral blood flow (rCBF) and error in rCBF. The calculational limitations of the technique are discussed and an experimental estimate made of the physical limitations associated with the low energy photon emitted by 133Xe. The method is demonstrated in a rhesus monkey model before and after surgical occlusion of the middle cerebral artery.