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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
73
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

269
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
269
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Updated: May 15, 2025

Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
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The Multidisciplinary Approach to Acute Necrotizing Pancreatitis.

Dana Ben-Ami Shor1, Einat Ritter1, Tom Borkovsky1

  • 1Department of Gastroenterology, Tel-Aviv Sourasky Medical Center, Affiliated to the Faculty of Medicine, Tel-Aviv University, Tel Aviv 6997801, Israel.

Journal of Clinical Medicine
|May 14, 2025
PubMed
Summary
This summary is machine-generated.

Severe acute pancreatitis, often caused by gallstones or alcohol, can lead to organ failure. Treatment involves supportive care, antibiotics, and interventions like endoscopic ultrasound (EUS)-guided drainage for infected fluid collections.

Keywords:
acute pancreatitisdirect endoscopic necrosectomyendoscopic drainagenecrotizing pancreatitis

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Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Surgical Gastroenterology

Background:

  • Acute pancreatitis is a frequent gastrointestinal disorder, with gallstones and alcohol abuse as primary triggers.
  • While often mild, severe cases (up to 20%) involve pancreatic necrosis, leading to multi-organ failure and increased mortality.
  • Management strategies range from conservative care to invasive interventions for complications.

Purpose of the Study:

  • To outline the management of acute pancreatitis, focusing on severe necrotizing forms.
  • To highlight the role of interventions in managing infected peripancreatic fluid collections (PFCs).
  • To emphasize the importance of a multidisciplinary approach in severe cases.

Main Methods:

  • Conservative management: fluid resuscitation, nutritional support, antibiotics for infected PFCs.
  • Invasive interventions: endoscopic ultrasound (EUS)-guided drainage, percutaneous drainage for persistent symptoms or infected PFCs.
  • Direct endoscopic necrosectomy for refractory cases.

Main Results:

  • Dual-modality drainage (endoscopic and percutaneous) shows improved outcomes and reduced complications.
  • Invasive procedures are crucial when conservative management fails or complications arise.
  • A coordinated, multidisciplinary team approach is vital for successful patient outcomes.

Conclusions:

  • Effective management of severe acute pancreatitis requires a tiered approach, starting with conservative measures and progressing to invasive interventions as needed.
  • Combined endoscopic and percutaneous drainage strategies offer significant benefits in managing infected PFCs.
  • Optimal care for severe necrotizing pancreatitis necessitates collaboration among various medical specialists.