[Effect of leponex on the ultrastructure of the brain]

Electron microscopic examination of the black substance, olfactory tubercle and head of the rat caudate nucleus was made upon a single and a 3-week administration of the antipsychotic drug leponex in a dose of 10 mg/kg. It was shown that leponex induces hyperproduction of the mitochondria, changes in sizes and form of neuronal bodies and processes, and the formation of the membranous structures in presynaptic endings. These changes were attended by ultrastructural shifts in neurons and glia. The data are considered as compensatory processes of mediator receptors of the brain.