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Updated: May 15, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Initial Investigation of the Direct Incorporation of the 1,1,2-Trifluoroethyl Substituent into Organic Compounds
Satyajit Majumder1, Md Nirshad Alam1, William R Dolbier1
1Department of Chemistry, University of Florida, Gainesville, Florida 32611-7011, United States.
Abstract:
The 1,1,2-trifluoroethyl substituent should have considerable potential in the design of new biologically active molecules, combining the beneficial qualities of a more metabolically stable CH2F substituent and the positive electron-withdrawing impact of a fluoroalkyl substituent. A synthetic source of the 1,1,2-trifluoroethyl substituent has now been designed, synthesized, and utilized. Thus, the synthesis of diphenyl(1,1,2-trifluoroethyl)sulfonium trifluoromethanesulfonate and its use in the direct incorporation of the 1,1,2-trifluoroethyl substituent into a variety of organic molecules via visible light/photoredox and nucleophilic chemistry is reported in this paper.
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