Quercetin Enhances GLP-1 Secretion via TAS2R38-Mediated PLC Signaling in Enteroendocrine L-Cells
Chenxuan Wang1, Jiefang Zhou1, Xiaojing Liu1
1College of Food Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Abstract:
Quercetin (QC), a natural flavonoid, has shown potential in regulating glucose homeostasis by promoting glucagon-like peptide-1 (GLP-1) secretion. This study investigates the role of the bitter taste receptor TAS2R38 and the phospholipase C (PLC) signaling pathway in QC-induced GLP-1 secretion from enteroendocrine NCI-H716 cells. Molecular docking revealed strong binding between QC and TAS2R38. QC significantly enhanced GLP-1 secretion, which was attenuated by TAS2R38 siRNA and PLC inhibitors. These findings suggest that QC stimulates GLP-1 release through TAS2R38-mediated PLC signaling, offering a novel mechanism for QC's antidiabetic effects.
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