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Transcriptional co-regulator OCA-B/Pou2af1 restricts Th2 differentiation

Erik P Hughes1,2, Asit K Manna1,2, Wenxiang Sun2

  • 1Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, United States.

Frontiers in Immunology
|May 14, 2025
PubMed
Summary

OCA-B restricts type 2 helper T cell responses by interacting with GATA3, limiting allergic inflammation. This finding reveals a novel regulator of Th2 immunity.

Keywords:
Bob1CD4+ T cellsGata3OCA-BPou2af1Th2

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