The molecular mechanisms, roles, and potential applications of PANoptosis in cancer treatment
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Wenyuan Ma1, Qiang Wang2, Lanfang Guo3
1Department of Pathology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang Clinical Medical College of Jiangsu University, Danyang, Jiangsu, China.
Abstract:
PANoptosis, a newly identified form of programmed cell death regulated by the panoptosome complex, exhibits key characteristics of apoptosis, pyroptosis and necroptosis. It exerts a substantial influence on the initiation and progression of a spectrum of diseases, particularly in cancer, where its impact is increasingly being recognized. PANoptosis is closely related to tumorigenesis, carcinogenesis, metastasis, chemotherapy resistance, as well as the prediction of therapeutic responses and prognosis in cancer patients. In this review, we first review the discovery of PANoptosis and systematically analyze the composition of the panoptosome. Subsequently, we examine the role of PANoptosis in various types of cancer, encompassing its function within the tumor microenvironment, its role in tumor drug resistance, and its predictive role in cancer prognosis. Ultimately, we delve into strategies for targeting PANoptosis in cancer therapy, including targeting various molecules in the PANoptosis pathway, such as ZBP1, RIPK1, RIPK3, Caspases and other novel strategies like nanoinducers and viral vectors. This review aims to provide references and assistance for the research and application of PANoptosis in cancer treatment.
Insights
PANoptosis, a programmed cell death pathway, is crucial in cancer development and treatment response. Targeting the panoptosome complex offers new therapeutic strategies for various cancers.
Area of Science:
- Cell Death Research
- Oncology
- Molecular Biology
Background:
- PANoptosis is a novel programmed cell death mechanism involving the panoptosome complex.
- It shares features with apoptosis, pyroptosis, and necroptosis.
- PANoptosis significantly impacts cancer initiation, progression, and therapeutic outcomes.
Purpose of the Study:
- To review the discovery and mechanisms of PANoptosis.
- To analyze the role of PANoptosis in cancer, including its involvement in the tumor microenvironment and drug resistance.
- To explore therapeutic strategies targeting PANoptosis in cancer treatment.
Main Methods:
- Systematic review of existing literature on PANoptosis.
- Analysis of the panoptosome complex composition.
- Examination of PANoptosis's role in various cancer types and its therapeutic implications.
Main Results:
- PANoptosis is implicated in tumorigenesis, metastasis, and chemotherapy resistance.
- The panoptosome complex composition and its regulatory roles are detailed.
- PANoptosis influences tumor microenvironment dynamics and predicts patient prognosis.
Conclusions:
- Targeting PANoptosis, including key molecules like ZBP1 and caspases, presents promising therapeutic avenues.
- Novel strategies such as nanoinducers and viral vectors are being explored.
- Understanding PANoptosis is vital for advancing cancer research and treatment.
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